Glycocalyx & its Roles in Inflammation & Atherosclerosis

£86.99 £115.99

Glycocalyx & its Roles in Inflammation & Atherosclerosis

Name: Glycocalyx & its Roles in Inflammation & Atherosclerosis
Brand: Nova Science Publishers, Inc
Price: 86.99 GBP
Availability: InStock

Written by Ye Zeng

£86.99 £115.99

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The major component of glycocalyx, heparan sulfate covalently attaches to proteoglycan core proteins, which is abundant at the cell surface and in the extracellular matrix. Heparan sulfate could provide binding sites on endothelial cells to retain and activate highly diffusible cytokines and inflammatory chemokines to regulate cell functions, such as proliferation and migration. Under physiological and pathological conditions, the remodeling in structure of heparan sulfate including the abnormal expression, and irregular distribution that critically play a fundamental role in inflammation and atherosclerosis, as well as many other diseases was observed. This book aims to integrate a current understanding of the identified molecular mechanisms in the regulation of glycocalyx, especially the heparan sulfate structure. Additionally, the available drugs that can protect the heparan sulfate or induce its synthesis, and the measurement techniques of the endothelial glycocalyx, as well as the relationship between structure and function of heparan sulfate in the progression of inflammation and atherosclerosis are analysed.

ISBN-13: 9781634858250
Publisher: Nova Science Publishers, Inc
Imprint: Nova Science Publishers, Inc
Publication date: 1 December 2016
Format: Paperback
Pages: 125
Dimensions: 230 x 155 mm
Language: English