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Type I Interferon in Autoimmune Diseases & its Clinical Applications
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£189.74
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£252.99
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Type I Interferon in Autoimmune Diseases & its Clinical Applications
Sale price
£189.74
Regular price
£252.99
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Auto-immune diseases such as systemic lupus erythematosus (SLE), Sjögren's syndrome, psoriasis, scleroderma (SSc) and myositis are heterogeneous disorders that result from interactions between genetic and environmental factors. Type I interferons (IFNs), especially IFN-α/β, have multiple biological functions including anti-viral and anti-bacterial properties, immuno-modulation, anti-proliferation, and intensive studies over decades have also revealed important roles in auto-immunity and cancer. Sustained Type I IFN elevation has been implicated in immune responses against self-antigens and tissue damage, which has led to the hypothesis that type I IFN might play a critical role in the pathogenesis of some auto-immune and inflammatory diseases. This book provides an overview of many key topics surrounding type I IFNs, beginning with detailed discussion of the type I IFN signalling pathway, the interplay between components that regulate this pathway, its involvement in auto-immunity, and a detailed review of the roles of type I IFNs in a series of well characterised inflammatory and auto-immune diseases.
- ISBN-13
- 9781624173790
- Publisher
- Nova Science Publishers Inc
- Publication date
- 19 June 2013
- Format
- Hardback
- Pages
- 349
- Dimensions
- 260 x 180 mm
- Language
- English
