Histone Deacetylase Inhibitors (HDIs)

Name: Histone Deacetylase Inhibitors (HDIs)
Brand: Nova Science Publishers, Inc (US)
Price: 119.99 GBP
Availability: InStock

Pharmacology, Uses & Health Effects

Written by Beverly D Carson

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Histone deacetylase inhibitors (HDIs) are good anti-cancer targets. Histone acetyltransferases (HATs) and HDIs play opposite roles in the regulation of gene expression via an epigenetic mechanism. HATs catalyse the acetylation of lysine residues in histone tails, facilitating and sustaining gene transcription. HDIs remove the acetyl moieties from the epsilon-amine of lysine residues of histone tails, leading to a more condensed form of chromatin and preventing gene transcription. This book focuses on the use of HDIs for the treatment of lymphoid malignancies; myeloid malignancies; and breast cancer.

ISBN-13: 9781634638357
Publisher: Nova Science Publishers, Inc
Imprint: Nova Science Publishers, Inc (US)
Publication date: 1 June 2015
Format: Hardback
Pages: 95
Dimensions: 230 x 155 mm
Language: English