{"product_id":"9781624173790","title":"Type I Interferon in Autoimmune Diseases \u0026 its Clinical Applications","description":"Auto-immune diseases such as systemic lupus erythematosus (SLE), Sjögren's syndrome, psoriasis, scleroderma (SSc) and myositis are heterogeneous disorders that result from interactions between genetic and environmental factors. Type I interferons (IFNs), especially IFN-α\/β, have multiple biological functions including anti-viral and anti-bacterial properties, immuno-modulation, anti-proliferation, and intensive studies over decades have also revealed important roles in auto-immunity and cancer. Sustained Type I IFN elevation has been implicated in immune responses against self-antigens and tissue damage, which has led to the hypothesis that type I IFN might play a critical role in the pathogenesis of some auto-immune and inflammatory diseases. This book provides an overview of many key topics surrounding type I IFNs, beginning with detailed discussion of the type I IFN signalling pathway, the interplay between components that regulate this pathway, its involvement in auto-immunity, and a detailed review of the roles of type I IFNs in a series of well characterised inflammatory and auto-immune diseases.","brand":"Nova Science Publishers, Inc (US)","offers":[{"title":"Default Title","offer_id":65430545367389,"sku":null,"price":189.74,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1041\/3893\/2573\/files\/9781624173790.jpg?v=1789232365","url":"https:\/\/shop.gazellebookservices.co.uk\/products\/9781624173790","provider":"Gazelle Book Services","version":"1.0","type":"link"}