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Specialized sections address intrauterine devices, surgical techniques, male contraception, and emergency interventions, alongside critical considerations such as drug interactions, cancer risk, and the non-contraceptive benefits of hormonal methods. The book also explores contraception in special populations, including adolescents and perimenopausal women, and provides an informed perspective on the development of hormonal methods for male use. Clinical pearls, pharmacological foundations, and structured assessment guidelines ensure that the content is both academically robust and readily applicable at the bedside. Whether for exam preparation, patient consultation, or continuous professional development, Advances in Reproductive Health: A Clinical Guide to Contraception is an indispensable resource for informed, patient-centered reproductive care.","brand":"Nova Medicine and Health","offers":[{"title":"Default Title","offer_id":64670597415261,"sku":null,"price":152.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1041\/3893\/2573\/files\/9798901340387.jpg?v=1788892296"},{"product_id":"9781932922868","title":"12 Body System Charts Set","description":"Suitable for healthcare professions, patients, students, educators and parents, this title is designed as reference material to increase knowledge of the human body. 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The Human Genome Project, with its goal of producing detailed maps of the 23 pairs of human chromosomes and sequencing the three billion nucleotide bases that make up the human genome, has been instrumental in the identification of genes implicated in various diseases including glaucoma, colon cancer, and cystic fibrosis. With the identification of these genes comes the hope of genetic therapies to cure disease but this scientific accomplishment is not without potential problems. For instance the presence of a cancer causing gene may indicate a predisposition but does not guarantee that the person will contract the disease: How should an employer or insurer respond? The ethical, social, and legal implications of these technological advances have been the subject of significant scrutiny and concern. 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This collaboration also stresses the vital role art can play in critiquing these biomedical technologies, particularly as advancements in science begin to challenge our ethical boundaries.","brand":"University of Alberta Press","offers":[{"title":"Default Title","offer_id":65418143662429,"sku":null,"price":22.49,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1041\/3893\/2573\/files\/9780888645081_51cc0536-fbc8-4980-88c3-472ca002e297.jpg?v=1789422148"},{"product_id":"9798891130807","title":"Dendritic Spines: An Update","description":"The book \"Dendritic Spines. An Update” aims to describe the ultimate knowledge regarding the dendritic spines-mediated synaptic transmission. The book approaches dendritic spines development and adult spinogenesis, as well as the physiological properties associated to their structural plasticity. 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Also this book gives a perspective about study steps of metabolomics, the relationship of different diseases and metabolites, and the use of metabolomics in the treatment processes of different clinical pictures and diseases in the light of current information obtained from the literature. This book aims to describe all types of contents, effects, and kinetics of metabolite production related with metabolomics, as well as to summarize from the beginning to the end. Because the significance of metabolomics science and clinical trials increases day by day. Some diseases like cancer are an important cause of mortality for which no definitive treatment has yet been found. Further investigation of the relationship between metabolomics and diseases will open new horizons for diagnosis and treatment of many kind of diseases. 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Therefore, this book gives an introduction to metal biology and does so in a unique manner. It is based on research conducted at the University of Limerick, Ireland. It is written with students in Food and Health Sciences interested in metals and a delicious dinner. To describe the biological cycle of metals, the book starts with unique recipes developed by the students, cooked with selected ingredients based on the content of a specific metal, thereby creating a dish with maximum metal content. We then follow each metal through the gastrointestinal system, explore its distribution in the body, and describe its major functions until it is finally excreted, and the reader is hungry for the next metal and meal. This book is written for students in Life Sciences, especially Physiology, Food and Health Sciences, Nutritional Sciences, Biosciences, related fields, researchers, teachers, and the interested public. Every day, we make choices about what we eat. 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Chapter Three reviews the loss of Insulin-like growth factor 2 (IGF2) imprinting in human tumors, focusing especially on the mechanisms underlying this abnormality in epigenetic control; and summarizes recent progress on targeting this tumor specific imprinting abnormality as a novel anti-cancer approach.","brand":"Nova Science Publishers, Inc","offers":[{"title":"Default Title","offer_id":65421509820765,"sku":null,"price":139.49,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1041\/3893\/2573\/files\/9781536102444.jpg?v=1789487427"},{"product_id":"9781536104318","title":"Down Syndrome (DS)","description":"Down syndrome (DS), also known as Trisomy 21, is a chromosomal disorder in which a third copy of the 21st chromosome affects both structural and behavioral development of one in every 800 live births in the United States. DS is a very common cause of mental impairment and children with DS present with a variety of medical issues, including cardiovascular defects, endocrine problems, neurodevelopment disorders, hematological problems, gastrointestinal and sleep dysfunctions, visual and hearing impairment. This book provides new research on the perspectives, challenges and management of DS. Chapter One examines the control of force and timing during finger tapping sequences of adolescents with Down syndrome. Chapter Two reviews the management of executive function following Assisted Cycling Therapy (ACT) in adolescents with DS. Chapter Three evaluates retrospectively the data of auxological and endocrinological parameters in patients with this genetic disorder.","brand":"Nova Science Publishers, Inc","offers":[{"title":"Default Title","offer_id":65421645545821,"sku":null,"price":139.49,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1041\/3893\/2573\/files\/9781536104318.jpg?v=1789488300"},{"product_id":"9781536119510","title":"Psychosocial Needs","description":"With the conclusion of adolescence, a child develops into a teenager that may experiment with dating, smoking and drinking, and they may make important decisions without parental knowledge or guidance. These teenagers may also engage in risky behaviour, which may pose as a threat to their well-being and successful transition into adulthood. With this in mind, how can we can prevent adolescent risk behaviour? Traditionally, prevention scientists propose three forms of prevention. Primarily, attempts to reduce the harmful consequences of risk behaviour, such as treatment of risk behaviour (ie: mental disorders or substance abuse) are ideal. For some problematic behaviour which has already occurred, a better approach is to identify those who are at-risk as early as possible (ie: secondary prevention). For example, youth workers may identify those who have suicidal ideation and intervene as early as possible so that they will not harm themselves. In this book, the authors assess whether a community-based program in Hong Kong was effective in promoting adolescent development and explore what factors were associated with the program effects. The authors hope that the studies included in this book can help to reveal the successful experience of the project and provide some pointers for the development of programs for adolescents with greater psychosocial needs.","brand":"Nova Science Publishers, Inc","offers":[{"title":"Default Title","offer_id":65422148436317,"sku":null,"price":152.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1041\/3893\/2573\/files\/9781536119510.jpg?v=1789492602"},{"product_id":"9781536121322","title":"Liposomes","description":"Chapter One is addressed to a comprehensive revision of the bibliography regarding the emergence of liposomes and the first steps in their design, the type of systems (components and structures), their classification and properties. Chapter Two discusses the possibility of creating living synthetic cells. Chapter Three provides an overview of the development and application of liposomes in biomedical sciences, with special emphasis on recent advances in the investigation of multifunctional liposomes that target cells and cellular organelles with a single delivery system. In Chapter Four, the authors review the mechanisms of drug transport through the BBB using liposomes, and the design strategies for optimum liposomal properties. In Chapter Five, the development rationales and structural types of pH-sensitive liposomes is discussed Chapter Six presents the characteristic, classification and preparation methods of liposomes. To develop liposomal drug delivery system, functional liposomes including antibody-conjugating liposomes known as immunoliposomes and stimuli-triggered liposomes such as pH- and thermo-sensitive liposomes have been investigated in Chapter Seven. Chapter Eight covers the use of thermosensitive liposomes for drug delivery and cancer therapy, because the side-effects of anticancer drugs are restrained and drug release can be controlled in combination with local hyperthermia. In Chapter Nine, the authors summarise the potential of OMLs as a novel adjuvant and antigen delivery vehicle for induction of encased antigen-specific strong T cell immunity. Chapter Ten presents the recent advances of liposomes in drug and vaccine delivery and shed light to the application of DSC to thermodynamic characterisation of liposomal delivery platforms. Chapter Eleven focuses on various liposomal delivery systems that are currently being explored to overcome the anatomical and physiological obstacles to improve the delivery efficiency of BNCT to brain glioma cells.","brand":"Nova Science Publishers, Inc","offers":[{"title":"Default Title","offer_id":65422317191517,"sku":null,"price":182.99,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1041\/3893\/2573\/files\/9781536121322.jpg?v=1789493540"},{"product_id":"9781536122046","title":"Essureal Journey","description":"Hysteroscopic sterilisation (HS) is the most important, and perhaps most revolutionary, advancement in female sterilisation over the past 100 years. Soon after receiving FDA approval in 2002, the Essure® system became the preferred, non-incisional alternative to standard tubal ligation. 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Chapter Two discusses oestradiol signalling pathways and how deficiency of oestrogen, in the postmenopausal period, would cause CVS diseases and the potential therapeutic effect of oestrogen for preventing cardiovascular diseases in postmenopausal women. Chapter Three covers a project that was undertaken to obtain an unbiased survey of differential gene expression in the liver in response to oestrogen, TAM, and RAL.","brand":"Nova Science Publishers, Inc","offers":[{"title":"Default Title","offer_id":65422374338909,"sku":null,"price":73.49,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1041\/3893\/2573\/files\/9781536122985.jpg?v=1789494290"},{"product_id":"9781536123982","title":"Face Processing","description":"Face processing is now a mainstream, multi-faceted and global research field in psychology, and it is growing exponentially. The volume of emerging research necessitates continuous efforts to update our overall understanding of current theory. This book brings together contributions from face processing researchers around the world to provide up-to-date reviews of topics of great current interest. The book is partitioned to give insight into face processing systems, such as those employed to verify a persons identity in applied security settings, the state-of-the-art systems utilised for the construction of criminal facial composites in police investigations, and the cognitive systems for the recognition of familiar faces and bodies; disorders, focusing on people with extremely high and extremely poor face processing ability, as well as face processing in autism spectrum disorder; and cultural differences, including the development of perceptual and social race biases, the impact of cultural headdress traditions and reading directions on face perception, cultural similarities and differences in the processing of facial expressions, as well as a broader look at ethnicity, gender and age biases in face processing. The outcome is a book that provides diverse, interesting, useful and thought-provoking chapters, covering a range of topics of current theoretical and applied importance, authored by a combination of internationally renowned and exciting upcoming researchers.","brand":"Nova Science Publishers, Inc","offers":[{"title":"Default Title","offer_id":65422400684381,"sku":null,"price":139.49,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1041\/3893\/2573\/files\/9781536123982.jpg?v=1789299661"},{"product_id":"9781536125092","title":"Arterioles","description":"The knowledge of the morphofunctional features from the coronary microcirculation is essential for understanding its role in cardiac physiological work and in the pathogenesis of coronary microvascular dysfunction (CMD). The cardiovascular system comprises the heart and blood vessels, including arteries, veins, and capillaries, both systemic and pulmonary. Arterioles are the primary site of vascular resistance and have only one to two layers of smooth muscular walls. Chapter One will provide an overview of the coronary microcirculation, its functions and regulatory mechanisms. The importance of CMD will be summarised in the context of diverse clinic scenarios, considering its pathogenesis, assessment and therapeutic management. The purpose of Chapter Two is to understand the role of arteriolar endothelial dysfunction in CVDs and its underlying mechanisms. Chapter Three will explore the physiopathology, epidemiology, and the diagnosis and treatment of hypertensive retinopathy. Chapter Four reports on angiogenesis, a critical process for reproduction in mammals, which consists of arterioles and blood vessels formation from the existing ones.","brand":"Nova Science Publishers, Inc","offers":[{"title":"Default Title","offer_id":65422457536861,"sku":null,"price":73.49,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1041\/3893\/2573\/files\/9781536125092.jpg?v=1789300246"},{"product_id":"9781536126235","title":"Adult Stem Cell Released Molecules","description":"Dr. Greg Maguire's thought-provoking book offers a radically new approach to the standard means of developing drugs through the use of the molecules that stem cells release. Emphasizing that living organisms operate through the collective actions of entities within and between all levels of the biological organism, including the quantum level, molecular level, and cellular level, for example, the argument is put forth that drug development, and medicine itself, must treat various indications by understanding and then treating the collective actions at the relevant levels that are found to be perturbed in that particular indication. Motivated by the recent successes in the fields of quantum collective electrodynamics and condensed matter physics, where systems level thinking has explained through mathematical and conceptual reasoning how these phenomenon work, and doing so with heuristic outcomes, Maguire argues that the same system level thinking must be applied to drug development and medicine. The interactive nature of these fundamental collective processes is at the core of developing systems therapeutics and, as such, challenges those that believe in fundamental reductionism, where understanding the components of the system will explain the system. During these times, fundamental reductionism is often used to explain diseases as the result of an aberration in a DNA sequence, and targeted approaches to drug development lead to the development of small molecules to specifically target only one pathway. Because of this, there is an understanding that diseases and other indications are multifactorial and often don't involve a genomic alteration; systems biology analysis should lead to systems therapeutics where multiple pathways, often at different levels of the organism, are targeted by the therapeutic aspects. The therapeutic development approach that Maguire explains is a result of reverse engineering endogenous adult stem cell function that serves to maintain and heal our tissues. Using the pools of molecules that different types of adult stem cells release, each pool of molecules being tissue specific for the indication to be treated, Maguire describes the systems therapeutic results. The book is divided into nine sections, each of which can be read as a standalone chapter and serve as a source of references on the particular topic. Although some of the topics use mathematical formulas, none of the material requires mathematical rigor in order to understand the concepts. The last chapter culminates in showing how the systems therapeutic approach using the molecules from adult stem cells is used to treat neurodegeneration.","brand":"Nova Science Publishers, Inc","offers":[{"title":"Default Title","offer_id":65422497612125,"sku":null,"price":139.49,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1041\/3893\/2573\/files\/9781536126235.jpg?v=1789300766"},{"product_id":"9781536126297","title":"Osteoclastogenesis","description":"Bone is a dynamic tissue that undergoes continual adaptations during a vertebrates lifespan to attain and preserve skeletal size, shape, and structural integrity, and plays a pivotal role in regulating mineral homeostasis in a living body. Bone homeostasis, which maintains bone mass, is artfully regulated through osteoclasts, osteoblasts and osteocytes in bone tissues. This mechanism is regulated through many hormones, cytokines and immune systems in the bone marrow microenvironment. Aging leads to a reduction in bone mass, which is reduced by a suppression of osteoblastic bone formation and an enhancement in osteoclastic bone resorption. A decrease in bone mass leads to osteoporosis and bone fracture. Osteoporosis is widely recognized as a major public health problem. Moreover, bone loss is shown to stimulate in various pathophysiological states, including inflammation, obesity, diabetes, and cancer cell bone metastasis. Disease associated with bone loss is strongly related to osteoclastic bone resorption. This book focuses recent research topics implicated in osteoclastogenesis and clinical challenges to prevent and treat bone loss.","brand":"Nova Science Publishers, Inc","offers":[{"title":"Default Title","offer_id":65422501183837,"sku":null,"price":86.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1041\/3893\/2573\/files\/9781536126297.jpg?v=1789300807"},{"product_id":"9781536129274","title":"Potassium Channels in Health and Disease","description":"Potassium ion (K+) channels are ubiquitous components and are widely distributed on the surface of the cell membrane in various tissues. There are many types of potassium ion channels (voltage-gated K+ channels, ATP-sensitive K+ channels, Ca2+-activated K+ channels, etc.), and each type of potassium ion channel has its own characteristic features concerning electrophysiology and molecular biology in each potassium ion channel. The potassium ion current across the plasma membrane is considered to have two main physiological functions, one for determining the membrane potential and the other regulating the electrical activity. Membrane hyperpolarization would reduce the excitability of the membrane by shifting the membrane potential away from the threshold for excitation and would inhibit, where it existed, calcium ion (Ca2+) influx through voltage-gated Ca2+ channels by closing the Ca2+ channel. Outward potassium ion currents activated upon depolarization would counteract the depolarizing action of inward currents carried either by sodium ion (Na+) or Ca2+. Therefore, potassium ion channels show the physiological effects in each tissue via membrane potential mediated Ca2+ dynamics (for example, excitation-contraction coupling in muscle). Potassium ion channel activity is also essentially regulated by the intracellular signal transduction pathways, such as receptors (G proteins) second messenger molecules processes in the physiological condition. On the other hand, the modification of potassium ion channel activity would be expected to have a significant effect on the excitability of various cells. Therefore, augmentation of outward potassium ion currents may be useful to treat various diseases (asthma, chronic pulmonary obstructive disease, hypertension, diabetes mellitus, glaucoma, arrhythmias, heart failure, epilepsy, etc.). Furthermore, potassium ion channels may be a target protein for the research and development of a therapeutic agent for various diseases concerning the lungs, heart, nerves, eyes, and pancreas. However, there are few books described in detail about potassium ion channels. This book will focus on the characteristics, function and regulation of several types of potassium ion channels, focusing on the role of these channels not only in terms of physical responses, but also in the aforementioned diseases.","brand":"Nova Science Publishers, Inc","offers":[{"title":"Default Title","offer_id":65422534312285,"sku":null,"price":86.99,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1041\/3893\/2573\/files\/9781536129274.jpg?v=1789302173"},{"product_id":"9781536130225","title":"Essureal Journey","description":"Hysteroscopic sterilization (HS) is the most important, and perhaps most revolutionary, advancement in female sterilization over the past 100 years. Soon after receiving FDA approval in 2002, the Essure® system became the preferred, non-incisional alternative to standard tubal ligation. Even as this innovative birth control technique continues to be offered to hundreds of thousands of women worldwide, the method is not without controversy. At present, no single work of reference summarizes the full HS picture, from its clinical trials to approval, its entry into the global medical market, and its post-marketing activity. This book fills an immediate niche as an essential reference for anyone interested in HS and its place in modern contraceptive practices. It is particularly well-suited for primary care physicians, reproductive surgeons, GPs, family nurse practitioners, gynecologists, womens healthcare providers, counselors, attorneys, reproductive ethicists, public health policy advocates, as well as patients and their partners.","brand":"Nova Science Publishers, Inc (US)","offers":[{"title":"Default Title","offer_id":65422554857821,"sku":null,"price":69.74,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1041\/3893\/2573\/files\/9781536130225.jpg?v=1789302649"},{"product_id":"9781536131680","title":"mRNA","description":"In this collection, the authors review the currently available data on interactions of ribosomal components with canonical mRNAs and with hepatitis C virus (HCV)-like IRESes during translation and on conformational rearrangements in the ribosomes accompanying these interactions. This review considers data obtained by biochemical approaches, primarily by site-directed cross-linking with the application of mRNA and IRES analogues bearing reactive groups in definite locations, and models for translational complexes of higher eukaryotic ribosomes derived from cryo-electron microscopy. Afterwards, the authors discuss how the addition of the poly(A) tail of 30-100 adenosines to the 3'-end of mRNA has been shown to be important for the stability, nuclear export, export of mRNA to the cytoplasm and translation of a transcript. The molecular mechanism responsible for the definition of a poly(A) site includes several recognition, cleavage and polyadenylation factors that identify the poly(A) signal, usually AAUAAA hexamer and similar variants, located 10-35 nucleotides upstream of the cleavage site. The process known as SUMO (small ubiquitin-related modifier) conjugation to a lysine residue in the target protein or sumoylation is a rapid, reversible post-transcriptional modification is also examined. Similar to ubiquitin, SUMO isoforms are conjugated to their targets by a isopeptide bond between their C-terminal glycine and the ɛ-NH2 group of the target lysine residue. Next, the authors discuss splicing of pre-mRNAs coding for proteins. Since the discovery of frequent spliceosomal gene mutations which occur in about 65% of patients with myelodysplastic syndrome (MDS), we know that splicing factor gene mutations are the most frequent mutations found in MDS patients. Predominantly, four splicing factor genes (SF3B1, SRSF2, U2AF1, ZRSR2) are mutated in MDS and related malignancies. In closing, the authors present their findings that splicing is not only necessary for obtaining correct open reading frames, but also leads to deposition of the exon junction complex core. Essentially, all pre-mRNAs are cleaved and polyadenylated with exception of histone mRNAs.","brand":"Nova Science Publishers, Inc (US)","offers":[{"title":"Default Title","offer_id":65422594539869,"sku":null,"price":73.49,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1041\/3893\/2573\/files\/9781536131680.jpg?v=1789303408"},{"product_id":"9781536132489","title":"Phagocytosis","description":"Phagocytosis is an elegant, but complex process that cells use for the ingestion and elimination of particles larger than 5 mm in diameter. Unicellular organisms use phagocytosis to eat, while complex pluricellular animals have special phagocytic cells, which can phagocytize microbial pathogens, foreign toxic substances, and apoptotic cells. The Russian scientist Elie Metchnikoff originally described phagocytosis in the late 19th century. The scientific community of the time strongly opposed phagocytosis as part of their defense mechanisms, since the view was that only humoral elements were responsible for immunity. The importance of this cellular process has become evident with time thanks to the efforts of many dedicated researchers. Today, phagocytosis is recognized as a fundamental process not only for immunity, but also for tissue homeostasis. Because phagocytosis is a very complex process, its molecular bases are not completely known. This book represents an effort to introduce our present understanding of phagocytosis through the contribution of several brilliant scientists that actually investigate phagocytosis on a daily basis. This book describes the history of phagocytosis and then the various steps of the phagocytic process from initial cell contact to phagosome formation, where the phagocytized particle is destroyed. Each chapter deals with one of these steps and emphasizes the molecules that participate at that step. The authors begin by describing the difficult origins of phagocytosis and how the cellular theory was finally recognized to be as important as the humoral theory of immunity. Next, the chapter \"Receptor Signaling During Phagocytosis\" talks about the signaling pathways of the major groups of phagocytic receptors, namely receptors for antibodies and complement. Then, the chapter The Role of Phosphoinositides in the Formation and Maturation of Phagosomes describes how these different membrane phospholipds regulate the changes in membrane composition during the process of phagocytosis. The following chapters deal with the mechanics of phagosome formation and membrane traffic for phagosome maturation. So, the chapter \"Phagosome Formation and Sealing: A Physical Point of View\" tells us about the cytoskeleton changes that bring about the closure of the new phagosome. The chapter Vesicular Trafficking: Golgi to Plasma Membrane describes the movement of internal membranes to the plasma membrane to allow the formation of the phagosome. The chapter Retinal Pigment Epithelial Cells: Super Phagocytes with a Rhythm describes an important example of how phagocytosis contributes to homeostasis. In the eye, the retinal pigment epithelium cells specifically phagocytize the photosensitive outer segment of photoreceptor cells following a diurnal rhythm. This contributes to the maintenance of a healthy retina. Finally, the chapter How Do Microbial Pathogens Escape from Phagocytosis? describes various mechanisms that some microbial pathogens have evolved to disrupt the phagocytic process and be able to survive in the host to perpetuate their infection. Each chapter can be read independently, but together all of the chapters offer a general view of phagocytosis. The book provides in this way a complete modern vision of this important biological function.","brand":"Nova Science Publishers, Inc (US)","offers":[{"title":"Default Title","offer_id":65422663352669,"sku":null,"price":152.99,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1041\/3893\/2573\/files\/9781536132489.jpg?v=1789303827"},{"product_id":"9781536132649","title":"Advances in Genetics Research","description":"In this collection, the authors present research supporting the claim that the study of autochthonous microbial communities is of crucial importance for understanding the genetic and biotechnological potential of bioremediation in environments close to the areas of extraction and susceptible to contamination. They discuss the main characteristics of petroleum, including its exploitation aspects, the process of geological formation, and environmental impacts. Following this, this book suggests that in case of accidental defects occurring in any part of the system, a coordinated counteraction of numerous mediators may successfully help in the restoration of physiologic processes by means of either overexpression or hyperactivity. Even serious defects of genome stabilizer mechanisms may be kept in balance for a long duration, showing the clinical signs of good health. The authors go on to discuss Rett Syndrome, a rare, neurodevelopmental genetic disorder that develops in early childhood and influences many functions within neurobehavioural domains. The core of phenotype symptoms includes severe linguistic and motor impairments. The correlations between genotype and motor abilities in subjects with Rett Syndrome are discussed. Next, this book examines Cornelia de Lange syndrome (CdLS) (also known as Bushy syndrome, Amsterdam dwarfism and Brachmann- de Lange syndrome) a genetic multi system disorder, usually caused by spontaneous mutation. The estimated occurence is about 1:10,000-30,000 births. A separate paper is presented illustrating the clinical variability of cognitive-behavioral phenotype in the different SCAs, determining that a precise identification of the cognitive and behavioral phenotype in different SCAs may enhance the clinical treatment, anticipatory guidance, and care throughout the lifespan. Transcranial direct current stimulation (tDCS), a non-invasive, painless brain stimulation treatment, is examined. tDCS uses direct electrical currents of low intensity to stimulate specific parts of the brain.","brand":"Nova Science Publishers, Inc (US)","offers":[{"title":"Default Title","offer_id":65422675280221,"sku":null,"price":192.74,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1041\/3893\/2573\/files\/9781536132649.jpg?v=1789303910"},{"product_id":"9781536133707","title":"An Essential Guide to Cytogenetics","description":"An Essential Guide to Cytogenetics explores the use of cytogenetic data for studies of frogs as well as the insights that hypotheses of phylogenetic relationships have added to this issue. The authors provide an overview of PcP190 satellite DNA, sex chromosome systems and B chromosomes found in Anura. This book also aim to establish the health effects of various activities and exposures by examining the levels of exposure and the biological effects resulting from the interaction between the organism and the chemical agent. Following this, a chapter is included which focuses on on the complex karyotype issues in myelodysplastic diseases, leukemias, lymphomas and multiple myelomas as the authors see them in daily practice in their center. The authors investigate hybridization, suggesting that the viability of a hybrid between species with a chromosomal discrepancy may offer important hypotheses to explain the morphological, molecular, and cytogenetic diversity of the genus. Trichorhinophalangeal syndrome is analyzed, suggesting that in cases of cytogenetically-invisible alterations, parental FISH analysis as well as aCGH should be considered as part of the clinical baseline testing.","brand":"Nova Science Publishers, Inc (US)","offers":[{"title":"Default Title","offer_id":65422747533661,"sku":null,"price":86.99,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1041\/3893\/2573\/files\/9781536133707.jpg?v=1789304441"},{"product_id":"9781536133721","title":"Circadian Clock","description":"In this collection, the authors review temporal control of tissue homeostasis and repair by the circadian system. The molecular regulation of circadian timing has been well-characterized in several species as a highly conserved transcriptional feedback loop that maintains roughly 24-hour cellular periodicity. A current challenge is determining how the outputs of the master clock affect peripheral oscillators and numerous biological processes. A subsequent study seeks a more detailed understanding of the physiology and molecular mechanism underlying circadian changes in the plasma of glucose, which might allow for the identification of novel targets for the developing therapeutic approached to the diabetes and obesity diseases. Procambarus acanthophorus, a burrower crayfish, follows a nocturnal circadian rhythm due to the way it spends long periods of time building tunnels to reach the water table during the dry season. Therefore, it follows that this species must have a close relationship with soil. The authors suggest that soil might be an ecological factor with high perceived value, influencing ecological aspects, and physiological functions such as growth, reproduction, and organization of the circadian system. The genes involved in the maintenance of circadian rhythm and its impact on the immunological system are described as disruption of the circadian rhythm leads to significant alterations of the organism and is associated with several biological responses. In the concluding review, some of the most useful characteristics of zebrafish for studying the molecular, cellular, and behavioral aspects of the circadian clock system are described. Zebrafish have been established as an attractive vertebrate model for the examination of light signaling pathways and their impact on the cellular clock because zebrafish cellular clocks have an unusual attribute of being directly light responsive. Additionally, the molecular components of the mammalian and zebrafish cellular clocks are highly similar.","brand":"Nova Science Publishers, Inc (US)","offers":[{"title":"Default Title","offer_id":65422748090717,"sku":null,"price":73.49,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1041\/3893\/2573\/files\/9781536133721.jpg?v=1789304454"},{"product_id":"9781536135183","title":"Ubiquitin Proteasome System","description":"Over the last decade, major advancements in our understanding of the ubiquitin-proteasome system (UPS) have occurred. This book focuses on recent trends in the UPS. The UPS is possibly the most complex of all intracellular pathways  as close to 7% of all genes in the human genome make up part of the UPS. This complex system serves as an essential role in intracellular protein degradation, and because of its critical function, improper functioning of the UPS is associated with nearly all know diseases, including cancer, cardiovascular disease, and neurological diseases. The proteolytic component of the UPS is the proteasome, a multicatalytic complex found in the nucleus and cytoplasm. Another form of the proteasome, the immunoproteasome, is less abundant than the constitutive proteasome, but is important in immune response and degradation of oxidized proteins, and recent research suggests that it may be important in longevity. The articles in this book discuss recent findings which indicate that mutations in proteins involved with the UPS are associated with genetic diseases such as familial dilated cardiomyopathy, Nakajo syndrome, and spinal muscular atrophy (X-linked). Some chapters also discuss recent results which suggest that the UPS is heavily regulated by post-translational modifications such as phosphorylation, acetylation, and methylation. The UPS is also heavily regulated by ubiquitination itself. This book contains a research article using PubMed bibliometric data to present current research trends in the UPS. Articles are written so that no one tissue is emphasized to allow readers from any discipline to benefit from this information.","brand":"Nova Science Publishers, Inc (US)","offers":[{"title":"Default Title","offer_id":65422781415773,"sku":null,"price":152.99,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1041\/3893\/2573\/files\/9781536135183.jpg?v=1789305196"},{"product_id":"9781536136265","title":"New Research on Cell Aging and Death","description":"New Research on Cell Aging and Death reviews previous literature to describe the main behavioral and biochemical characteristics of the SAMP8 mouse model, discussing its main advantages as well as potential weaknesses to model age-related diseases. The subsequent chapter discusses the effect of the mechanism of cell death of neutrophil granulocytes on the realization of the inflammatory process. Neutrophil granulocytes play a central role in the innate nonspecific defense response of the human organism. In addition, neutrophils infiltrate secondary lymphoid organs where they regulate the development of adaptive immunity. Later, the authors suggest that in C. albicans, apoptotic mechanisms are valuable as major strategies with several characteristics such as phosphatidylserine exposure, DNA fragmentation, and activation of metacaspase. Studying antifungal agents with varying mechanisms of action can be effective in appropriately treating potentially fatal candidiasis. In one study, the authors evaluated the effects of natural and chemical compounds on promoter activities of several human DNA repair-associated genes in HeLa S3 cells. . The results indicated that naturally occurring compounds, for example, trans-resveratrol, upregulate TP53 promoter activity. Sustaining an appropriate level of genes encoding DNA repair factors is thought to be necessary for cell survival by preventing the accumulation of DNA mismatches and epigenetic alterations. The concluding review focuses on the effects of aging on adult neurogenesis, a process of producing new neurons from neural stem cells and neural progenitor cells in the neocortex, comparing the dentate gyrus and subventricular zone.","brand":"Nova Science Publishers, Inc (US)","offers":[{"title":"Default Title","offer_id":65422811955549,"sku":null,"price":86.99,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1041\/3893\/2573\/files\/9781536136265.jpg?v=1789305768"},{"product_id":"9781536138177","title":"Myosin","description":"Myosin: Biosynthesis, Classes and Function opens with a discussion on class I myosins, the most varied members of the myosin superfamily and a remarkable group of molecular motor proteins that move actin filaments and produce force. Class I myosin molecules have various physiological roles including maintenance of normal intestinal brush border structure, glucose homeostasis, glomerular filtration, immune function, and tumor promotion and suppression, and new studies are revealing that mutations may lead to diseases including cancer and kidney disease. Thus, the authors review the structure and function of the eight myosin-I isoforms (Myo1a-Myo1h) that are expressed in mammals. Next, the book discusses muscle contractile function and its association with the activity of the protein complex actomyosin, in which myosin exhibits enzyme activity, namely the ability to hydrolyze ATP. The demonstrated ability of calix[4]arenes C-97, C-99, C-90 and thiacalix[4]arenes C-798 and C-800 can be used for further research aimed at the use of these compounds as novel pharmacological agents able to efficiently restore normal contractile function of myometrium by inhibition or activation of this function, or the eliminating negative effects of heavy metal cations. Following this, the authors present the results of their experiments on studying the effects of different isotopes of magnesium and zinc on the enzymatic activity of myosin, namely the catalytic subfragment-1 of myosin, isolated from myometrium muscle. It has been revealed that the rate of the enzymatic ATP hydrolysis is 22.5 times higher in the reaction media enriched with the magnetic isotope, 25Mg, as compared to the activity of the same enzyme in the reaction media enriched with the nonmagnetic isotopes, 24Mg or 26Mg or MgCl2 of natural isotope abundance. Continuing, precipitation\/extraction methods and MALDI TOF\/TOF mass spectrometry were used in order to and identify, for the first time, a protein with the molecular mass of 48 kDa as a fragment of human unconventional myosin 1c isoform b in a blood serum of multiple sclerosis patients. Western-blot analysis using commercial monospecific anti-human Myo1c antibodies has shown that the molecular mass of this protein obtained from a blood serum of different human sources varied in between 46-48 kDa. Thus, the authors name the 46-48 kDa proteins revealed in a blood serum as a short form of the human unconventional myosin 1c (sMyo 1C).","brand":"Nova Science Publishers, Inc (US)","offers":[{"title":"Default Title","offer_id":65422839120221,"sku":null,"price":86.99,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1041\/3893\/2573\/files\/9781536138177.jpg?v=1789306703"},{"product_id":"9781536139860","title":"Mucopolysaccharidoses Update","description":"Mucopolysaccharidoses (MPS) are caused by a deficiency of lysosomal enzyme activities needed to degrade glycosaminoglycans (GAGs), which are long unbranched polysaccharides consisting of repeating disaccharides. GAGs include: Chondroitin sulfate (CS), dermatan sulfate (DS), heparan sulfate (HS), keratan sulfate (KS), and hyaluronan. Their catabolism may be blocked singly or in combination depending on the specific enzyme deficiency. There are eleven known enzyme deficiencies, resulting in seven distinct forms of MPS with a collective incidence higher than 1 in 25,000 live births. Accumulation of undegraded metabolites in lysosomes gives rise to distinct clinical syndromes. Generally, the clinical conditions progress if untreated, leading to developmental delay, systemic skeletal deformities, and early death. Other clinical features include coarse facial features, corneal clouding, recurrent ear and nose infections, inguinal and umbilical hernias, hepatosplenomegaly, heart valvular disease and skeletal deformities. Clinical features related to bone lesions may include marked short stature, cervical stenosis, pectus carinatum, small lungs, joint rigidity (but laxity for MPS IV), kyphoscoliosis, lumbar gibbus, and genu valgum. Patients with MPS are often wheelchair-bound and physical handicaps increase with age as a result of progressive skeletal dysplasia, abnormal joint mobility, and osteoarthritis. Patients may need multiple orthopedic procedures including cervical decompression and fusion, carpal tunnel release, hip reconstruction and replacement, and femoral or tibial osteotomy throughout their lifetime. Current measures to intervene in bone disease progression and CNS involvement are not perfect and palliative, and improved therapies are urgently required and are being proposed. Enzyme replacement therapy (ERT), hematopoietic stem cell transplantation (HSCT), and gene therapy are available or in development for some types of MPS. Delivery of sufficient enzymes to the brain and bones, especially avascular cartilage, to prevent or ameliorate the devastating neurological defects and skeletal dysplasias remains an unmet challenge. The use of an anti-inflammatory drug is also under clinical study. Therapies should start at a very early stage prior to irreversible bone lesion and damage, since the severity of CNS involvement and skeletal dysplasia is associated with the level of activity in a patients daily life. For the maximum benefit of available therapies, early detection and intervention are critical. Newborn screening and diagnostic systems have been developed by using tandem mass spectrometry. We review the history of diagnosis and newborn screening as well. Overall, this book illustrates a to-date overview of the pathogenesis, diagnosis, biomarkers, screening, and updated therapies as well as their impact on MPS, including ERT, HSCT, gene therapy, and anti-inflammatory drugs. History and activities of MPS societies are also described. It is a comprehensive textbook meant to cover many areas in the field of MPS and appeals to a broad spectrum of readers including physicians, scientists, students, pharmaceutical companies, and MPS communities.","brand":"Nova Science Publishers, Inc (US)","offers":[{"title":"Default Title","offer_id":65422866448733,"sku":null,"price":305.99,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1041\/3893\/2573\/files\/9781536139860.jpg?v=1789307611"},{"product_id":"9781536139907","title":"Bone Regeneration","description":"Bone regeneration is a complex process requiring an orchestrated number of molecular and cellular mechanisms. Although bone regeneration takes place throughout a lifetime for normal healing, regeneration may be impaired by pathological states such as osteoporosis, osteonecrosis, and non-union fractures. Currently, a number of therapies are available for treating pathogenesis, such as autologous bone grafts, small molecule agents, tissue engineering, and the use of osteoprogenitor cells. Other therapies including small compounds, growth factors, and cytokines are being used for a targeted approach. Orthobiologics are also being used for healing bones. The use of mesenchymal stem cells and osteoprogenitor cells as enhancers of healing is also being considered as a regenerative therapeutic approach. Biomaterial approaches using synthetic osteoconductive scaffolds are already in clinical use and continue to advance and gain traction as regenerative aids. Recent advances in scientific understanding of the molecular and cellular processes underlying bone regeneration have elevated therapeutic techniques to new frontiers. This book provides an overview of the bone biology in normal homeostasis and in pathological conditions, along with clinical therapies currently considered and those being developed for future use. Considering bone health is essential for maintaining the health of vertebrate animals as a whole. While bones are susceptible to injury, they also have excellent regenerative capacities, which bring about great interest among researchers in varied disciplines. In this book, we have compiled a series of chapters from the diverse points of view of experts in different fields. The cellular and molecular mechanisms regulating bone biology are examined at length. The importance of hormonal regulation on bone homeostasis and in pathological states is explored over several chapters from different vantage points. The unique role of the vascular system in bone regeneration and the molecular mechanisms involved are discussed. Clinical advances in bone healing are described, and current research on biomaterials and stem cell based approaches is presented. These chapters provide a number of perspectives on what is currently known and being discovered in the field of bone biology, which impacts the clinical approaches used today and in the future.","brand":"Nova Science Publishers, Inc (US)","offers":[{"title":"Default Title","offer_id":65422866809181,"sku":null,"price":182.99,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1041\/3893\/2573\/files\/9781536139907.jpg?v=1789307631"},{"product_id":"9781536144512","title":"Encyclopedia of Genetics","description":"This 8 volume encyclopedia set presents important research on genetics. Some of the topics discussed herein include the speciation of Arabian gazelles, tau alternative splicing in Alzheimer's disease, Cornelia de Lange syndrome and autosomal dominant polycystic kidney disease.","brand":"Nova Science Publishers, Inc","offers":[{"title":"Default Title","offer_id":65423031009629,"sku":null,"price":916.49,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1041\/3893\/2573\/files\/9781536144512.jpg?v=1789309808"},{"product_id":"9781536144970","title":"Severe Hypercholesterolemia Phenotype","description":"This book raises very important issues that concern the severe hypercholesterolemia phenotype. The severe hypercholesterolemia phenotype such as familial hypercholesterolemia (FH) is characterised by increased plasma low density lipoprotein (LDL) cholesterol concentration above 190 mg\/dl, regardless of the cause. The majority of patients with FH present mutations in genes controlling LDL concentration, such as genes caused by abnormalities in the LDL receptor protein function and clearance of the LDL particle. The most frequent mutations causing FH are observed in LDLR, ApoB and PCSK9 genes. However, a polygenic origin is also probable in several of FH cases. The marked elevation of plasma LDL cholesterol concentration leads to premature and severe cardiovascular disease, including death, regardless of the gene mutation. Particularly, in individuals with a homozygous form of FH (two identical mutations or compound heterozygotes). Thus, early diagnosis and treatment of FH is vital, since the risk of premature coronary heart disease is estimated to be approximately 20-fold higher in untreated FH patients compared with control subjects. On the contrary, the aggressive lowering of plasma LDL cholesterol concentration decreased the cardiovascular events. A hypolipidemic diet and lipid lowering drugs are the first steps in the treatment of FH patients. The most severe and resistant FH cases are treated with LDL apheresis on top of combined drug therapy. Consequently, the combination of classical hypolipidemic drugs and newly introduced medications, such as PCSK9 inhibitors, antisense oligonucleotide against APOB-100 (mipomersen) and microsomal triglyceride transfer protein inhibitors (lomitapide) provide a way for most FH patients to achieve LDL cholesterol treatment goals.","brand":"Nova Science Publishers, Inc","offers":[{"title":"Default Title","offer_id":65423072526685,"sku":null,"price":139.49,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1041\/3893\/2573\/files\/9781536144970.jpg?v=1789310015"},{"product_id":"9781536145434","title":"Resistin","description":"Over the past decade, adipose tissue has received much attention for its immunological properties. Additionally, it has become increasingly apparent that adipose-secreted factors such as leptin, tumor necrosis factor-a, IL-6, adiponectin and more recently, resistin are implicated in some inflammatory and metabolic diseases. As such, Resistin: Structure, Function and Role in Disease opens by discussing resistins therapeutic properties. Because evidence appears to suggest that resistin is a proinflammatory cytokine, resistin may impact metabolic disease.Following this, the authors present experimental and clinical evidence indicating that resistin may have functions related to inflammation and oxidative stress. The circulating resistin level may be also useful as a marker of the effects of exercise.Resistin may also encourage vasculopathy through the promotion of macrophage scavenger receptors and CD36 atheroma macrophages expression, the formation of foam cells, as well as proliferation and migration of vascular smooth muscle cells. This causes endothelial dysfunction, resulting in limited nitric oxide and increased superoxide production.When present in the diseased vessel wall, resistin may orchestrate pro-atherosclerotic events, contributing to atherosclerosis progression towards plaque rupture. Thus, resistin may augment monocyte and macrophage infiltration, interfere in cell cross-talk and modulate the expression of various inflammatory cytokines leading to the acceleration of plaque growth.Based on the known sequential events of obesity preceding severe acute pancreatitis, the authors investigate resistin as a new potential predictive marker of fat necrosis and pancreatitis severity.","brand":"Nova Science Publishers, Inc","offers":[{"title":"Default Title","offer_id":65423119188317,"sku":null,"price":86.99,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1041\/3893\/2573\/files\/9781536145434.jpg?v=1789310263"},{"product_id":"9781536150469","title":"Uterine Fibroids","description":"Uterine myomas are the most common form of benign uterine tumors, occurring in 50-60% of women. Clinically, they are mostly asymptomatic, often incidentally found on pelvic examination or by routine gynecological ultrasonographic evaluation; otherwise, in 30-40% of cases, they cause a large variety of symptoms, depending on their location and size. Currently, the therapeutic options for myomas are medical, radiological, and surgical. The aim of this book is to summarize the evidence regarding epidemiology, pathogenesis, clinical presentation, diagnosis and management of uterine myomas.","brand":"Nova Science Publishers, Inc","offers":[{"title":"Default Title","offer_id":65423601369437,"sku":null,"price":152.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1041\/3893\/2573\/files\/9781536150469.jpg?v=1789312683"},{"product_id":"9781536150537","title":"Mitochondrial Respiratory Chain Disorders","description":"Mitochondrial respiratory (MRC) disorders are a phenotypically and genetically diverse group of diseases which have an estimated incidence of 1 in 5000, and can manifest at any age with virtually any symptom. These disorders are generally progressive and multi-systemic, typically affecting organs with high energy demands, although potentially any organ can be affected. In view of their wide spectrum of clinical symptoms, together with their complex genetics, the diagnosis of these disorders presents a real challenge and usually requires a multidisciplinary approach involving clinical, genetic, histological, and biochemical investigations. In addition, an MRC defect may also occur as a secondary consequence of disease pathophysiology, as well as drug toxicity, further complicating the diagnostic algorithm for these disorders. The accurate diagnosis of MRC disorders is also hindered by the lack of reliable and validated biomarkers or surrogates for evaluating evidence of MRC dysfunction. Treatment options for MRC disorders are quite limited with no actual cure as yet in sight. Currently, apart from supportive therapies to manage the various clinical presentations of these diseases, patients can receive a host of antioxidants, vitamins, and cofactors in an attempt to maximize residual MRC function, and to combat the oxidative stress associated with these diseases. However, at present there appears to be a distinct lack of consensus on the appropriate treatment regime to instigate in patients with these disorders. Although, it is hoped that the establishment of national and international cohorts of patients with MRC disorders will allow the development of a unified approach to the development of candidate strategies for the treatment of these patients. In recent years, pharmacotherapies aimed at enhancing mitochondrial biogenesis have received a lot of attention, with some of them now being used in phase II clinical trials to assess evidence of their therapeutic efficacy in patients.  The purpose of this book is to outline the clinical presentation and the genetic and non-genetic causes of MRC disorders, as well as highlighting evidence of secondary mitochondrial dysfunction in disease. In addition, the current biochemical methods used in the diagnosis of MRC dysfunction will be discussed together with the potential future developments in this field. The current treatment options available to patients with MRC disorders will also be discussed together with novel, biochemical, therapeutic strategies which have yet to reach clinical application.","brand":"Nova Science Publishers, Inc","offers":[{"title":"Default Title","offer_id":65423605727581,"sku":null,"price":63.74,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1041\/3893\/2573\/files\/9781536150537.jpg?v=1789312748"},{"product_id":"9781536153552","title":"A Closer Look at Polyadenylation","description":"In response to various environmental cues and cellular stress, cells need to modify their protein expression pattern for proper cell functioning. The cell experiences diverse cellular stress as oxidative, genotoxic, and etc. The damage of the genome by certain chemicals or agents affects the cell integrity and leads to genotoxic stress. As such, this compilation discusses how different cellular stresses affect the polyadenylation process and modulate the polyadenylation machinery. Cytoplasmic polyadenylation plays an important role in oocyte maturation, mitotic cell cycle progression, cellular senescence and synaptic plasticity. Poly(A) tails can be elongated post-transcriptionally by noncanonical poly(A) polymerases, which can impact cells with limited transcriptional activity. A recent study is discussed wherein it is shown that that alternative cleavage and polyadenylation isoform expression influences about 10% of targeting by miRNAs between any two cell types analysed and, more importantly, that the accuracy of target prediction can be improved if the cellular alternative cleavage and polyadenylation profile is considered. The authors go on to focus on how altering the polyadenylation process and components of RNA polyadenylation machinery leads to abnormal physiological conditions. The targeting of elements of RNA polyadenylation machinery as therapeutics in clinical research is also discussed. The majority of eukaryotic mRNAs are polyadenylated at their 3'end. This poly(A) tail is not encoded by DNA and is added co-transcriptionally. Cleavage and polyadenylation specific factor (CPSF1) is part of multiple subunit factors required for a site-specific cleavage, which is involved in determining specificity and efficency of the 3' end processing of pre-mRNAs in the nucleus by recognizing the polyadenylation signal. Following this, mutations in the poly(A) signal (AAUAAA hexamer) present in the globin pre-mRNA were identified in hematological disorders caused by defects in the synthesis of one or more of the globin chains (thalassemia). The point mutation AATAAA to AACAAA of a human β-globin gene detected in 1985 in DNA from a patient with β-thalassemia led to the formation of an elongated β-globin mRNA isoform. This compilation addresses how RNA processing at the pre-mRNA level occurs in the cell nucleus and regulates gene expression. Newly synthesized mRNA contains a poly(A) tail, which is added through canonical polyadenylation coupled to transcription. Canonical mRNA 3' processing involves endonucleolytic cleavage within the pre-mRNA sequences and the addition of a poly(A) tail to the upstream cleavage fragment. The closing chapter discusses how the poly(A) tail at the 3'end of the majority of eukaryotic messenger RNAs (mRNAs), with the exception of histone transcripts, is not simply a static entity but more likely a dynamic matter. Its length added to an mRNA is regulated by the concerted action of poly(A) polymerases and deadenylases.","brand":"Nova Science Publishers, Inc","offers":[{"title":"Default Title","offer_id":65423702262109,"sku":null,"price":63.74,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1041\/3893\/2573\/files\/9781536153552.jpg?v=1789314187"},{"product_id":"9781536154474","title":"Acetylcholine Receptors in Health and Disease","description":"Acetylcholine Receptors in Health and Disease opens with a review of the results of an investigation on the cholinergic modulation of excitatory synaptic transmission in the frog tectum carried out in the laboratory of neurophysiology at the Lithuanian University of Health Sciences. Experiments were done in vivo on the common grass frog Rana temporaria. Next, the authors review the function of M4 MR and discuss possible detection methods. M4 MR regulated locomotion is studied in conjunction with recent data on consequences to biorhythms. In the closing chapter, the authors review the environmental enrichment paradigm in rodents, as well as their effects on neurobiological, physiological and behavioral variables in preclinical studies.","brand":"Nova Science Publishers, Inc","offers":[{"title":"Default Title","offer_id":65423730803037,"sku":null,"price":54.74,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1041\/3893\/2573\/files\/9781536154474.jpg?v=1789314631"},{"product_id":"9781536154689","title":"Manipulation of Stem Cells for Disease Benefits","description":"This collection of articles deals with the benefits of different types of stem cells sources, use, manipulation, and aspects for the treatment of chronic diseases. Topics include the role of calcium channel pathway\/s in the regulation of neural stem cell differentiation; the evolutionary roles of the totipotent, pluripotent, or even multipotent stem cells; the derivations of multipotent MSCs; and potential canine-derived stem cell therapies for dogs. The scope of the book also provokes further studies into other topics, such as MSC differentiation into hepatocytes and the involvement of these cells with microRNA-133 in type 1 diabetes; the role of Vitronectin in the differentiation into endoderm; the extent to which the stemness of dental pulp stem cells might be useful; PBMCs as a source for pluripotent stem cells; yoga in possible synergy with the finding that bone marrow stromal cells provide relief from a laboratory reagent used as drug-mediated pain in spinal cord injury.","brand":"Nova Science Publishers, Inc","offers":[{"title":"Default Title","offer_id":65423746531677,"sku":null,"price":152.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1041\/3893\/2573\/files\/9781536154689.jpg?v=1789314732"},{"product_id":"9781536161175","title":"DNA","description":"Deoxyribonucleic acid, or DNA, is the fundamental building block for an individual's entire genetic makeup. DNA is a powerful tool for law enforcement investigations because each person's DNA is different from that of every other individual (except for identical twins). As early as the 1980s, states began enacting laws that required the collection of DNA samples from offenders convicted of certain sexual and other violent crimes. Chapter 1 provides an overview of how DNA is used to investigate crimes and help protect the innocent. Chapters 2 and 3 report on the establishment of a system for integration of Rapid DNA instruments for use by law enforcement to reduce violent crime and reduce the current DNA analysis backlog. Chapter 4 examines what is known about the amount of backlogged DNA evidence at state and local government labs; the extent to which OJP measures CEBR grant performance; and the extent to which OJP has designed controls to identify conflicts of interest related to CEBR grants. Chapter 5 reviews the level of crime scene DNA evidence backlogs among CEBR grantees and the factors that contribute to such backlogs; the extent to which DOJ has clearly defined goals for CEBR; and the extent to which OJP has controls for CEBR related to federal conflicts of interest and lobbying requirements. In 2016, about 323,000 individuals age 12 or older were reported victims of sexual assault, according to the Bureau of Justice Statistics. Studies have shown that exams performed by sexual assault forensic examiners -- medical providers trained in collecting and preserving forensic evidence -- may result in better physical and mental health care for victims, better evidence collection, and higher prosecution rates. Chapter 6 describes what was known in 2016 about the availability of sexual assault forensic examiners nationally and in selected states and the challenges selected states faced in maintaining a supply of sexual assault forensic examiners.","brand":"Nova Science Publishers, Inc","offers":[{"title":"Default Title","offer_id":65423877538141,"sku":null,"price":106.49,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1041\/3893\/2573\/files\/9781536161175.jpg?v=1789317775"},{"product_id":"9781536167832","title":"Pre- and Postnatal Psychology and Medicine","description":"Pre- and postnatal psychology and medicine belong closely together, encompassing anthropological, biological and psychological aspects. Both psychoanalysis and infant mental health research have contributed largely to the subject, as have neonatology and social pediatrics. The human being seems to commence at the point of birth, when families are founded. Yet even before, during the prenatal period, significant influences on the unborn child and on mothers-to-be have been observed on different levels. The volume contributes to integrating clinical theory and practice through presenting research findings from the maternal perspective and from both the unborn and the infant perspective, putting them in a practical context. It emphasizes the need to view the human being as bio-psycho-social being, thus providing a possible integration of psychic and somatic approaches. Topics included are, among others, psychosomatic obstetrics, unborn and infant development, fetal brain development, parental dealings with preterm delivery, neonatal care, psychotherapy, and medical psychology of reproduction. Clinical accounts from international experts serve a panoramic view of pre- and postnatal factors affecting human personality, providing readers with seminal issues from conception through child development.","brand":"Nova Science Publishers, Inc","offers":[{"title":"Default Title","offer_id":65424030237021,"sku":null,"price":129.74,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1041\/3893\/2573\/files\/9781536167832.jpg?v=1789321087"},{"product_id":"9781536169751","title":"A Comprehensive Guide to Genetic Counseling","description":"In this compilation, the authors describe the psychological consequences and effects of predictive cancer genetic testing in both breast and ovarian cancer. Predictive genetic tests are being offered to an increasing number of women as the availability and public awareness of genetic testing increases. Next, A Comprehensive Guide to Genetic Counseling assesses the parental psychosocial implications, such as emotions and coping, regarding the earlier diagnosis of Usher syndrome via genetic testing compared to parents of children who were diagnosed later via ophthalmologic findings The closing chapter reports on a comprehensive analysis of the studies performed on genetic counseling, particularly those pertaining to the Israeli Arab society. Furthermore, an overview of the various socio-demographic, economic, cultural and religious aspects is provided.","brand":"Nova Science Publishers, Inc","offers":[{"title":"Default Title","offer_id":65424050061661,"sku":null,"price":63.74,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1041\/3893\/2573\/files\/9781536169751.jpg?v=1789322057"},{"product_id":"9781536169843","title":"Gene Mutations","description":"A gene is a DNA sequence that can be transcribed into an RNA molecule and transferred to offspring organisms. Changes in DNA sequences that determine the structure and function of a gene are called mutations. Gene Mutations: Causes and Effects opens by exploring the physical, chemical, and biological agents that cause mutations interact with DNA, leading to genetic instability. Recent advances in next-generation sequencing have led to the discovery of new causative genes or those mutations. The authors describe the phenotypes and gene mutations, discussing genotype-phenotype correlations compared with previous reports. Lastly, one study analyses all conflicting data concerning the amplification of the ESR1 gene, particularly its ambiguous prevalence in both untreated tumors and tumors either responsive or unresponsive to antiestrogen therapy.","brand":"Nova Science Publishers, Inc","offers":[{"title":"Default Title","offer_id":65424051601757,"sku":null,"price":54.74,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1041\/3893\/2573\/files\/9781536169843.jpg?v=1789322120"},{"product_id":"9781536171785","title":"A Closer Look at Autopsies","description":"From its earliest forerunners in Egyptian mummification and the influence of Herophilus and Galen in ancient Greece, the autopsy has deep roots in the historical effort to understand the human body. Advances in modern post-mortem examination technique, such as non-invasive imaging, will continue to shape the structure and role of the autopsy as it evolves and changes into the future. The autopsy is a major aspect of the practice of medicine which is used to audit the effectiveness of clinical practice and assist the law courts in the adjudication of cases in which deaths occurred in suspicious circumstances in order to guarantee a safe society, prevent secret homicide, premature deaths and avoid miscarriage of justice. Practical, legal and ethical aspects of the molecular autopsy method are also discussed. Early diagnosis by genetic testing will force lifestyle modifications in individuals with genetic risk factors, which alone or in combination with other therapeutic options may delay the onset of the disease. On-site examinations at autopsy in forensic practice are discussed. Since such \"on-site\" examinations are simple and not time-consuming, the results can be obtained promptly and may be useful for forensic diagnosis. Autopsy rates have dramatically declined in the last several decades. As such, the authors explore the myriad of aspects that may be contributing to this downward trend. At a societal level, autopsies play a crucial role in public health and the justice system. They are necessary in understanding the causes and course of epidemic outbreaks and recognizing the emergence of new diseases. The goal of the concluding chapter is to examine religious beliefs around death and common reasons why religion may be invoked when deciding not to consent to an autopsy. Religions that will be examined include Judaism, Islam, Christianity, Christian Science, Church of Jesus Christ of Latter Day Saints, Jehovah's Witness, Hinduism, and Buddhism.","brand":"Nova Science Publishers, Inc","offers":[{"title":"Default Title","offer_id":65424099311965,"sku":null,"price":63.74,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1041\/3893\/2573\/files\/9781536171785.jpg?v=1789323039"},{"product_id":"9781536174373","title":"Advances in Genetics Research","description":"Volume 19 extensively reviews a few important aspects of genetic diversity, including: the importance of genetic diversity in livestock and agriculture, the assessment of different procedures to get a precise measure of genetic diversity, factors affecting genetic diversity, and strategies to prevent such losses. Continuing, this compilation discusses genomic instability, which has been observed in several inherited pathological conditions. Mutations causing the disorder, as well as genomic instability, were present in genes associated to different biochemical functions such as: calcium influx or ionic permeation. The authors discuss short sequence repeats or microsatellite markers, which have been utilized extensively in livestock because they can be easily amplified and possess large amounts of allelic variation at each locus. The authors also explore a new commercially available test that can identify fetal chromosomal abnormalities by analyzing fetal nucleic acids circulating in a maternal blood sample. This test can be done before 10 weeks and can replace traditional first-trimester non-invasive screening. The causes underlying inbreeding depression and heterosis are analyzed, allowing for new insights into these phenomena as the result of a diploid genome structure, creating the states of homozygosity and heterozygosity. The relation of inbreeding depression and heterosis to the major biological processes is demonstrated. The closing study discusses default sex from different points of view, proposing a conception \"germ cell-supported female default\" in vertebrate gonadal somatic cells, as well as the idea that most vertebrate sex-determining genes emerged as destruction factors against the female default.","brand":"Nova Science Publishers, Inc","offers":[{"title":"Default Title","offer_id":65424178610525,"sku":null,"price":166.49,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1041\/3893\/2573\/files\/9781536174373.jpg?v=1789324247"},{"product_id":"9781536178753","title":"Connective Tissue","description":"The human body is composed of four basic kinds of tissue: nervous, muscular, epithelial, and connective tissue. Connective tissue is the most abundant type and serves as a connecting link for binding, supporting and strengthening all other body tissues. In this compilation, the authors explore connective tissue grafts, a promising and reliable method that provides a satisfactory esthetic outcome, making it a popular option for clinicians. The fundamentals of subepithelial connective tissue grafts, harvesting techniques, clinical success and possible postoperative complications is also discussed. (Imprint: Nova Medicine and Health)","brand":"Nova Science Publishers, Inc","offers":[{"title":"Default Title","offer_id":65424315384157,"sku":null,"price":63.74,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1041\/3893\/2573\/files\/9781536178753.jpg?v=1789331178"}],"url":"https:\/\/shop.gazellebookservices.co.uk\/collections\/medicine-basic-sciences.oembed","provider":"Gazelle Book Services","version":"1.0","type":"link"}